Exploration of protein and genetic targets causing atrioventricular block: mendelian-randomization analyses based on eQTL data and pQTL data

Abstract Background Atrioventricular block (AVB) is a heterogeneous group of arrhythmias. AVB can lead to sudden arrest of the heart and subsequent syncope or sudden cardiac death. Few scholars have investigated the underlying molecular mechanisms of AVB. Finding molecular markers can facilitate und...

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Hlavní autoři:	Tongyu Wang, Peipei Ma, Xiaofang Wang, Yunlong Xia
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-10-01
Edice:	BMC Cardiovascular Disorders
Témata:	Atrioventricular block eQTL pQTL Mendelian randomization Reverse mendelian randomization Drug targets
On-line přístup:	https://doi.org/10.1186/s12872-024-04209-y
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