Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein

Mutational inactivation of NPC1 largely blocks the movement of LDL-derived cholesterol from the lysosome to the metabolically active, cytosolic pool of sterol that is the substrate for steroid hormone production. Such a block might, in theory, lead to deficiencies in circulating levels of testostero...

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Bibliografische Detailangaben

Hauptverfasser:	Chonglun Xie, James A. Richardson, Stephen D. Turley, John M. Dietschy
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2006-05-01
Schriftenreihe:	Journal of Lipid Research
Schlagworte:	adrenal gland ovary testis lipoprotein receptors corticosterone testosterone
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0022227520332430
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