Elevated level of mitochondrial reactive oxygen species via fatty acid β-oxidation in cancer stem cells promotes cancer metastasis by inducing epithelial–mesenchymal transition

Abstract Background Cancer stem cells (CSCs) play a critical role in tumor development and progression and are involved in cancer metastasis. The role of reactive oxygen species (ROS) in CSCs and cancer metastasis remains controversial. The aim of the present study was to investigate the correlation...

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Detalhes bibliográficos

Principais autores:	Caihua Wang, Liming Shao, Chi Pan, Jun Ye, Zonghui Ding, Jia Wu, Qin Du, Yuezhong Ren, Chunpeng Zhu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-06-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Cancer stem cells Tumor sphere ROS Cancer metastasis Mitochondria Epithelial-mesenchymal transition
Acesso em linha:	http://link.springer.com/article/10.1186/s13287-019-1265-2
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