Evidence for Quasi-High-LET Biological Effects in Clinical Proton Beams That Suppress c-NHEJ and Enhance HR and Alt-EJ

Protons are conventionally regarded as a low-linear energy transfer (low-LET) radiation modality with a relative biological effectiveness (RBE) of 1.1, suggesting direct mechanistic similarity to X-rays in the underpinning biological effects. However, exposure to spread-out Bragg peak (SOBP) protons...

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Autori principali:	Emil Mladenov, Mina Pressler, Veronika Mladenova, Aashish Soni, Fanghua Li, Feline Heinzelmann, Johannes Niklas Esser, Razan Hessenow, Eleni Gkika, Verena Jendrossek, Beate Timmermann, Martin Stuschke, George Iliakis
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-01-01
Serie:	Cells
Soggetti:	ionizing radiation (IR) linear energy transfer (LET) relative biological effectiveness (RBE) proton radiation homologous recombination (HR) classical non-homologous end joining (c-NHEJ)
Accesso online:	https://www.mdpi.com/2073-4409/15/1/86
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