IgM Antibodies Can Access Cryptic Antigens Denied to IgG: Hypothesis on Novel Binding Mechanism

Antibodies are well-known protein mediators of immunity. IgM is the primordial member and the neglected sibling of the later-evolved and more proficient IgG in regard to their therapeutic and diagnostic use. Serendipitously, however, we found a paradox: While murine IgM antibodies specific for guano...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Eric Chun Yiu Law, Danny Tze Ming Leung, Frankie Chi Hang Tam, Kitty Kit Ting Cheung, Naomi Hua Yin Cheng, Pak Leong Lim
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2019-08-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	IgM antibody specificity guanosine triphosphate lock-and-key antigen-binding site steric hindrance
Онлайн хандалт:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01820/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!