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Investigating the initial steps of auricin biosynthesis using synthetic biology

Abstract Streptomyces lavendulae subsp. lavendulae CCM 3239 (formerly Streptomyces aureofaciens CCM 3239) contains a type II polyketide synthase (PKS) biosynthetic gene cluster (BGC) aur1 whose genes were highly similar to angucycline BGCs. However, its product auricin is structurally different from...

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Main Authors: Dominika Csolleiova, Rachel Javorova, Renata Novakova, Lubomira Feckova, Maria Matulova, Filip Opaterny, Bronislava Rezuchova, Beatrica Sevcikova, Jan Kormanec
Format: Artigo
Language:Inglês
Published: SpringerOpen 2023-08-01
Series:AMB Express
Subjects:
Antibiotics
Auricin
Biosynthetic gene cluster
Griseusin
Synthetic biology
Streptomyces
Online Access:https://doi.org/10.1186/s13568-023-01591-2
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