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Shigella mediated depletion of macrophages in a murine breast cancer model is associated with tumor regression.

A tumor promoting role of macrophages has been described for a transgenic murine breast cancer model. In this model tumor-associated macrophages (TAMs) represent a major component of the leukocytic infiltrate and are associated with tumor progression. Shigella flexneri is a bacterial pathogen known...

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Autores principales: Katharina Galmbacher, Martin Heisig, Christian Hotz, Joerg Wischhusen, Antoine Galmiche, Birgit Bergmann, Ivaylo Gentschev, Werner Goebel, Ulf R Rapp, Joachim Fensterle
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2010-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC2833200?pdf=render
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