CB2R agonism protects intestinal epithelium through β-catenin/HoxA10 loop in radiation injury

Abstract Background Radiation-induced intestinal injury (RIII) represents a significant dose-limiting complication of radiotherapy, characterized by substantial loss of intestinal epithelial cells (IECs). While the activation of cannabinoid receptor 2 (CB2R) is protective in immune‑mediated colitis,...

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Bibliografische Detailangaben

Hauptverfasser:	Qianyi Yao, Ying Tian, Yi Yuan, Yongqing Cai, Qunfang Yang, Lanfang Zhang, Yunong Li, Tanjun Wei, Yi Wang, Qin Ouyang, Haigang Zhang, Xiaoli Li, Tao Liu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-05-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	CB2R Ferroptosis Radiation-induced intestinal injury β-Catenin HoxA10
Online-Zugang:	https://doi.org/10.1186/s12967-026-08268-x
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