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Humans and Chimpanzees Display Opposite Patterns of Diversity in Arylamine N-Acetyltransferase Genes

Among the many genes involved in the metabolism of therapeutic drugs, human arylamine N-acetyltransferases (NATs) genes have been extensively studied, due to their medical importance both in pharmacogenetics and disease epidemiology. One member of this small gene family, NAT2, is established as the...

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Principais autores: Christelle Vangenot, Pascal Gagneux, Natasja G. de Groot, Adrian Baumeyer, Médéric Mouterde, Brigitte Crouau-Roy, Pierre Darlu, Alicia Sanchez-Mazas, Audrey Sabbagh, Estella S. Poloni
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019-07-01
coleção:G3: Genes, Genomes, Genetics
Assuntos:
Arylamine N-acetyltransferases
multigenic family
drug metabolism
great apes
natural selection
Acesso em linha:http://g3journal.org/lookup/doi/10.1534/g3.119.400223
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