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Molecular features of prenylated (iso)flavonoids from Fabaceae in relation to their potential NorA inhibition in Staphylococcus aureus

BackgroundThe overexpression of the NorA efflux pump is known to be an important factor in the antimicrobial resistance mechanism of Staphylococcus aureus. Therefore, NorA inhibition can help disarm this pathogen and tackle antimicrobial resistance. In this study, we aim to unravel the molecular pro...

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Principais autores: Marina Ika Irianti, Janniek Henrieke Ritsema, Jos Hageman, Jean-Paul Vincken, Carla Araya-Cloutier
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-01-01
coleção:Frontiers in Pharmacology
Assuntos:
efflux pump inhibitors
Fabaceae
fluoroquinolone
NorA
prenylated (iso)flavonoids
QSAR
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2025.1715533/full
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