Iron(III)-salophene catalyzes redox cycles that induce phospholipid peroxidation and deplete cancer cells of ferroptosis-protecting cofactors

Ferroptosis, a lipid peroxidation-driven cell death program kept in check by glutathione peroxidase 4 and endogenous redox cycles, promises access to novel strategies for treating therapy-resistant cancers. Chlorido [N,N′-disalicylidene-1,2-phenylenediamine]iron (III) complexes (SCs) have potent ant...

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Autori principali:	Fengting Su, Hubert Descher, Minh Bui-Hoang, Hermann Stuppner, Ira Skvortsova, Ehsan Bonyadi Rad, Claudia Ascher, Alexander Weiss, Zhigang Rao, Stephan Hohloch, Solveigh C. Koeberle, Ronald Gust, Andreas Koeberle
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-09-01
Serie:	Redox Biology
Soggetti:	Ferroptosis Iron complexes Reactive oxygen species Redox mechanism Lipidomics NADPH
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2213231724002350
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