Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1

Summary: Glioblastoma is the most aggressive and deadly form of brain cancer. Here, we leverage our human organoid tumor transplantation (HOTT) co-culture system to explore how extrinsic cues modulate glioblastoma cell types and behavior. HOTT recapitulates core features of major patient tumor cell...

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Hauptverfasser:	Weihong Ge, Ryan L. Kan, Can Yilgor, Elisa Fazzari, Patricia R. Nano, Daria J. Azizad, Heer Shinglot, Matthew Li, Joyce Y. Ito, Christopher Tse, Hong A. Tum, Jessica Scholes, Shivani Baisiwala, Kunal S. Patel, David A. Nathanson, Aparna Bhaduri
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-01-01
Schriftenreihe:	Cell Reports
Schlagworte:	CP: Cancer CP: Stem cell research
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124725016201
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