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Long-Term Consequences of High Titer Neutralizing Antibodies to Interferon-β in Multiple Sclerosis

BackgroundNeutralizing anti-drug antibodies (NAbs) to interferon beta (IFNβ) develop in up to 47% of multiple sclerosis (MS) treated patients inhibiting treatment effect of IFNβ. However, the long-term effect of NAbs remain unknown.ObjectiveTo investigate the long-term consequences of high titer NAb...

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Hoofdauteurs: Nicky Dunn, Anna Fogdell-Hahn, Jan Hillert, Tim Spelman
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020-10-01
Reeks:Frontiers in Immunology
Onderwerpen:
neutralizing antibodies
interferon-β
multiple sclerosis
immunogenicity
annual relapse rate
Online toegang:https://www.frontiersin.org/article/10.3389/fimmu.2020.583560/full
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