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Chromosomal aberration arises during somatic reprogramming to pluripotent stem cells

Abstract Background Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has opened new therapeutic possibilities. However, karyotypic abnormalities detected in iPSCs compromised their utility, especially chromosomal aberrations found at early passages raised serious safety concerns...

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Principais autores: Xinyu Liu, Conghui Li, Kang Zheng, Xiaofeng Zhao, Xiaofeng Xu, Aifen Yang, Min Yi, Huaping Tao, Binghua Xie, Mengsheng Qiu, Junlin Yang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2020-11-01
Serier:Cell Division
Fag:
Induced pluripotent stem cell
Reprogramme
Karyotype
Chromosomal aberration
Genetic stability
Online adgang:http://link.springer.com/article/10.1186/s13008-020-00068-z
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