Excessive ER-mitochondria coupling: A DRP1-driven mechanism underlying mitochondrial dysfunction and impaired autophagy in stress-induced depression-like behavior in mice

Background: Depression is a common psychiatric disorder characterized by heightened stress exposure and disruptions in neuronal signaling. Growing evidence suggests that mitochondrial dysfunction contributes to its pathophysiology. In particular, mitochondrial dynamics regulated by Dnm1l/Drp1 are cr...

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Detalhes bibliográficos

Principais autores:	Jia-Rui Zhang, Jia-Yan Zhang, Qing-Ya Sun, Chang Chen, Jing-Wei Yang, Nan Cheng, Zi-Wen Guo, Ruo-Nan Shuang, Wei Gu, Meng-Ying Zhai, Jin-Ao Duan, Wei-Wei Tao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-05-01
coleção:	Redox Biology
Assuntos:	Depression Mitochondrial-endoplasmic reticulum contact sites (MERCs) Mitochondrion Mitophagy drp1
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213231726001199
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