A Pooled Analysis of Eight Clinical Studies Suggests a Link Between Influenza-Like Symptoms and Pharmacodynamics of the Toll-Like Receptor-7 Agonist Vesatolimod

Abstract Introduction Vesatolimod is a Toll-like receptor-7 (TLR7) agonist in clinical development as part of a combination regimen for human immunodeficiency virus (HIV) cure. Influenza-like symptoms associated with TLR7-mediated immune activation have been reported in clinical trials of vesatolimo...

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Główni autorzy:	Sharon A. Riddler, Constance A. Benson, Cynthia Brinson, Steven G. Deeks, Edwin DeJesus, Anthony Mills, Michael F. Para, Moti N. Ramgopal, Yanhui Cai, Yanan Zheng, Liao Zhang, Wendy Jiang, Xiaopeng Liu, Donovan Verrill, Daina Lim, Christiaan R. de Vries, Jeffrey J. Wallin, Elena Vendrame, Devi SenGupta
Format:	Artigo
Język:	Inglês
Wydane:	Adis, Springer Healthcare 2024-09-01
Seria:	Infectious Diseases and Therapy
Hasła przedmiotowe:	Toll-like receptor-7 agonist Vesatolimod Safety Influenza-like adverse events
Dostęp online:	https://doi.org/10.1007/s40121-024-01034-w
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