Itraconazole Amorphous Solid Dispersion Tablets: Formulation and Compaction Process Optimization Using Quality by Design Principles and Tools

BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so require solubility enhancement. Therefore, ITZ and Kollidon^® VA64 (KOL) amorphous solid dispersions (ASDs) were produced using hot-melt extrusion (HME) to improve ITZ’s poor solubility. A novel stra...

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Bibliografische Detailangaben

Hauptverfasser:	Hetvi Triboandas, Kendal Pitt, Mariana Bezerra, Delphine Ach-Hubert, Walkiria Schlindwein
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2022-11-01
Schriftenreihe:	Pharmaceutics
Schlagworte:	solubility enhancement amorphous solid dispersion (ASD) hot-melt extrusion (HME) itraconazole (ITZ) tablet compaction quality by design (QbD)
Online-Zugang:	https://www.mdpi.com/1999-4923/14/11/2398
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