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Novel CTRP8‐RXFP1‐JAK3‐STAT3 axis promotes Cdc42‐dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells

C1q tumor necrosis factor‐related peptide 8 (CTRP8) is the least studied member of the C1Q‐TNF‐related peptide family. We identified CTRP8 as a ligand of the G protein‐coupled receptor relaxin family peptide receptor 1 (RXFP1) in glioblastoma multiforme (GBM). The CTRP8‐RXFP1 ligand–receptor system...

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Principais autores: Aleksandra Glogowska, Thatchawan Thanasupawat, Jason Beiko, Marshall Pitz, Sabine Hombach‐Klonisch, Thomas Klonisch
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2022-01-01
Serier:Molecular Oncology
Fag:
actin remodeling
Cdc42
CTRP8
glioblastoma
relaxin
RXFP1
Online adgang:https://doi.org/10.1002/1878-0261.12981
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