Glycochenodeoxycholic acid promotes hepatocarcinogenesis by inducing hepatic progenitor cell differentiation into cancer-associated fibroblasts via sphingosine-1-phosphate receptor 2 signalling

Abstract Background Patients with advanced hepatocellular carcinoma (HCC) often develop cholestasis and exhibit poor clinical outcomes. Current evidence suggests that dysregulated bile acid metabolism may contribute to HCC progression, although the underlying molecular mechanisms remain unclear. Amo...

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Autori principali:	Lu Gao, Gang Lv, Ying Huang, Mengmeng Xue, Zhipeng Zhang, Jing Weng, Haoran Bai, Min Tao, Xi Luo, Yuhua Gao, Shiyao Feng, Xiaojuan Hou, Chen Zong, Xue Yang, Qiudong Zhao, Jinghua Jiang, Xinyu Zhu, Zhipeng Han, Changtao Jiang, Dongyu Zhao, Lixin Wei, Lulu Sun
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-12-01
Serie:	Biomarker Research
Soggetti:	Hepatocellular carcinoma Hepatic progenitor cells Cancer-associated fibroblasts Glycochenodeoxycholic acid Sphingosine-1-phosphate receptor 2
Accesso online:	https://doi.org/10.1186/s40364-025-00873-0
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