Personalized metronomic radiopharmaceutical therapy through injection profile optimization via physiologically based pharmacokinetic (PBPK) modeling

Abstract Each treatment cycle of radiopharmaceutical therapy (RPT) is administered as a single dose. We aimed to investigate a personalized metronomic RPT paradigm, employing multiple lower-dose administrations, to evaluate its effect on delivering radiopharmaceuticals to tumors. We developed a phys...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Aryan Golzaryan, M. Soltani, Farshad Moradi Kashkooli, Babak Saboury, Arman Rahmim
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-02-01
Colecção:	Scientific Reports
Assuntos:	PBPK modeling Personalized medicine Prostate cancer Metronomic radiopharmaceutical therapy Theranostics, ADME
Acesso em linha:	https://doi.org/10.1038/s41598-025-86159-9
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!