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P052 | THE PRESENCE OF TP53 VARIANTS REGARDLESS OF CO-MUTATIONAL PROFILE AFFECTS PROGNOSIS AND MODULATES WT1 TRANSCRIPTIONAL ACTIVITY IN PATIENTS WITH ACUTE MYELOID LEUKEMIA

A multicenter cohort of 59 patients with AML or MDS/AML harboring TP53 mutations, irrespective of variant allele frequency (VAF), was collected. Thirty-five patients had de novo AML (59.3%), 14 secondary AML (23.7%), 6 therapy-related AML (10.2%), and 4 MDS/AML (6.8%). The median age at diagnosis wa...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: R. Maffei, E. Toffoletti, F. Cretì, S. Martinelli, B. Conte, E. Ronda, L. Pochintesta, T. Liani, A. Paolini, G. Corradini, F. Giacobbi, L. Bonamici, B. Cambò, C. Papayannidis, E. Ottaviani, F. Forghieri, M. Luppi, F. Mosna, M. Tiribelli, A. Curti, A. Candoni, E. Tagliafico
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2025-09-01
Schriftenreihe:Haematologica
Online-Zugang:https://haematologica.org/article/view/12549
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