Microbiome dysbiosis and chemotherapy resistance in acute myeloid leukemia (AML)

Abstract AML often relapses due to chemotherapy resistance, increasingly linked to gut microbiome dysbiosis. Microbial drug modification, immune modulation, and metabolite-driven survival/epigenetic changes (e.g., SCFAs, kynurenine) promote resistance. Clinical data associate reduced diversity, loss...

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Autors principals:	Maojin Tian, Hamed Soleimani Samarkhazan, Seyed Shahabedin Alemohammad, Milad Fakhraei Manesh, Farzaneh Tavakoli, Ali Shams, Amirhossein Zeynalabadi
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-12-01
Col·lecció:	npj Biofilms and Microbiomes
Accés en línia:	https://doi.org/10.1038/s41522-025-00891-8
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