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Hypoxia-relieving and glycolysis-disrupting polydopamine nanomedicine for synergistic chemo-photothermal therapy of hepatocellular carcinoma

Hypoxia is a hallmark of solid tumors that compromises therapeutic efficacy in hepatocellular carcinoma (HCC). Here, a multifunctional polydopamine (PDA)-based nanomedicine co-loading shikonin (SK) and catalase (CAT) and functionalized with galactose (Gal) is developed and termed SC@PDA-Gal. SC@PDA-...

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Principais autores: Xiang Wang, Yihan Ma, Le Wang, Hengrui Li, Miao Qin, Ruonan Sun, Jing Hu
格式: Artigo
语言:Inglês
出版: Elsevier 2026-06-01
丛编:International Journal of Pharmaceutics: X
主题:
Hepatocellular carcinoma
Shikonin
Glycolysis
Pyruvate kinase M2
Chemo-photothermal therapy
在线阅读:http://www.sciencedirect.com/science/article/pii/S2590156726000265
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