Sigma-1R–CD36 axis in myeloid cells contributes to the alleviation of depression-like behaviors

Abstract Background Major depressive disorder (MDD) is a leading cause of disability and disease burden worldwide, and increasing attention has been paid to the role of immune dysregulation in MDD pathogenesis. However, the key cellular subsets, hub molecules, and their regulatory mechanisms have no...

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Hlavní autoři:	Meng Liang, Zhiding Wang, Ge Li, Chunxiao Du, Junrui Chen, Jiawen Lu, Miaonan Sun, Yanmin Lyu, Mengying Huang, Jixiang Sun, Yuxiang Li, Yanhong Liu, Jiangbei Cao, Gencheng Han, Yunfeng Li, Weidong Mi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-05-01
Edice:	Journal of Translational Medicine
Témata:	Major depressive disorder Monocytes/macrophages Single-cell RNA-seq Peripheral immunity CD36 Sigma-1R
On-line přístup:	https://doi.org/10.1186/s12967-026-08297-6
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