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Adult‐type granulosa cell tumor of the ovary: a FOXL2‐centric disease

Abstract Adult‐type granulosa cell tumors (aGCTs) account for 90% of malignant ovarian sex cord‐stromal tumors and 2–5% of all ovarian cancers. These tumors are usually diagnosed at an early stage and are treated with surgery. However, one‐third of patients relapse between 4 and 8 years after initia...

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Hlavní autoři: Jessica A Pilsworth, Dawn R Cochrane, Samantha J Neilson, Bahar H Moussavi, Daniel Lai, Aslı D Munzur, Janine Senz, Yi Kan Wang, Sina Zareian, Ali Bashashati, Adele Wong, Jacqueline Keul, Annette Staebler, Hannah S vanMeurs, Hugo M Horlings, Stefan Kommoss, Friedrich Kommoss, Esther Oliva, Anniina EM Färkkilä, Blake Gilks, David G Huntsman
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley 2021-05-01
Edice:The Journal of Pathology: Clinical Research
Témata:
adult‐type granulosa cell tumor of the ovary
FOXL2
TERT promoter
KMT2D
targeted sequencing
mutation profiling
On-line přístup:https://doi.org/10.1002/cjp2.198
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