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D-Ribose Induces Podocyte NLRP3 Inflammasome Activation and Glomerular Injury via AGEs/RAGE Pathway

D-ribose levels are demonstrated to be increased in type II diabetes mellitus and increased blood D-ribose is involved in the development of diabetic complications such as diabetic encephalopathy and nephropathy. However, the mechanism mediating the pathogenic role of D-ribose in nephropathy remains...

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Gardado en:
Principais autores: Jinni Hong, Guangbi Li, Qinghua Zhang, Joseph Ritter, Weiwei Li, Pin-Lan Li
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cell and Developmental Biology
Assuntos:
pentose monosaccharide
inflammatory machinery
AGEs-RAGE system
glomerular disease
end-stage renal disease
Acceso en liña:https://www.frontiersin.org/article/10.3389/fcell.2019.00259/full
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