Knock-in Kcnh2 rabbit model of long QT syndrome type-2, epilepsy, and sudden death

Abstract Background Long QT Syndrome Type-2 (LQT2) is due to loss-of-function KCNH2 variants. KCNH2 encodes Kv11.1 that forms a delayed-rectifier potassium channel in the brain and heart. LQT2 is associated with arrhythmias, seizures, sudden cardiac death, and sudden unexpected death in epilepsy (SU...

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Prif Awduron:	Veronica Singh, Kyle T. Wagner, Laura G. Williams, Justin M. Ryan, Katherine R. Keller, Jonathan D. Mohnkern, Robert S. Gardner, Louis T. Dang, Julie M. Ziobro, Richard J. H. Wojcikiewicz, Nathan R. Tucker, David S. Auerbach
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2025-04-01
Cyfres:	Journal of Translational Medicine
Pynciau:	Arrhythmia Seizure Epilepsy Long QT syndrome Rabbit KCNH2
Mynediad Ar-lein:	https://doi.org/10.1186/s12967-025-06382-w
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