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Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Phosphate Accelerates Cellular Cholesterol Efflux in THP-1 Cells

Cholesterol efflux is a major atheroprotective function of high-density lipoproteins (HDLs) which removes cholesterol from the foam cells of lipid-rich plaques in Type 2 diabetes. The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin phosphate increases plasma glucagon-like peptide-1 (GLP-1) conc...

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Principais autores: Tomohiro Komatsu, Satomi Abe, Shihoko Nakashima, Kei Sasaki, Yasuki Higaki, Keijiro Saku, Shin-ichiro Miura, Yoshinari Uehara
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-01-01
Serier:Biomolecules
Fag:
HDL
cholesterol efflux
DPP-4 inhibitor
GLP-1
ABCA1
apoA1
Online adgang:https://www.mdpi.com/2218-273X/13/2/228
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