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Specific macrophage RhoA targeting CRISPR-Cas9 for mitigating osteoclastogenesis-induced joint damage in inflammatory arthritis

Summary: Rheumatoid arthritis (RA) is the most prevalent inflammatory arthritis with unknown etiology, characterized by synovial inflammation and articular bone erosion. Studies have highlighted that inhibiting macrophage-induced osteoclastogenesis holds promise in mitigating bone destruction. Howev...

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Kaydedildi:
Asıl Yazarlar: Jianhai Chen, Jianwei Tan, Nannan Wang, Hui Li, Wenxiang Cheng, Jian Li, Benguo Wang, Adam C. Sedgwick, Zhitong Chen, Guojun Chen, Peng Zhang, Wei Zheng, Chengbo Liu, Jingqin Chen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2025-04-01
Seri Bilgileri:Cell Reports Medicine
Konular:
CRISPR-Cas9
osteoclastogenesis
rheumatoid arthritis
inflammatory arthritis
macrophages
two-photon imaging
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2666379125001193
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