H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape

Summary: Cancer-associated mutations in genes encoding histones dramatically reshape chromatin and support tumorigenesis. Lysine to methionine substitution of residue 27 on histone H3 (K27M) is a driver mutation in high-grade pediatric gliomas, known to abrogate polycomb repressive complex 2 (PRC2)...

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Detalhes bibliográficos

Principais autores:	Noa Furth, Danielle Algranati, Bareket Dassa, Olga Beresh, Vadim Fedyuk, Natasha Morris, Lawryn H. Kasper, Dan Jones, Michelle Monje, Suzanne J. Baker, Efrat Shema
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-05-01
coleção:	Cell Reports
Assuntos:	CP: Cancer CP: Molecular biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S221112472200609X
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