Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus

ABSTRACT Calcineurin is an essential virulence factor that is conserved across human fungal pathogens, including Cryptococcus neoformans, Aspergillus fumigatus, and Candida albicans. Although an excellent target for antifungal drug development, the serine-threonine phosphatase activity of calcineuri...

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Detaylı Bibliyografya
Asıl Yazarlar:	Michael J. Hoy, Eunchong Park, Hyunji Lee, Won Young Lim, D. Christopher Cole, Nicholas D. DeBouver, Benjamin G. Bobay, Phillip G. Pierce, David Fox, Maria Ciofani, Praveen R. Juvvadi, William Steinbach, Jiyong Hong, Joseph Heitman
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	American Society for Microbiology 2022-06-01
Seri Bilgileri:	mBio
Konular:	X-ray crystallography antifungal antifungal resistance antifungal susceptibility testing ascomycin calcineurin
Online Erişim:	https://journals.asm.org/doi/10.1128/mbio.01049-22
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Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus

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