Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency
The prevailing view is that the ClC-Ka chloride channel (mouse Clc-k1) functions in the thin ascending limb to control urine concentration, whereas the ClC-Kb channel (mouse Clc-k2) functions in the thick ascending limb (TAL) to control salt reabsorption. Mutations of ClC-Kb cause classic Bartter sy...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical investigation
2021-10-01
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| Serie: | JCI Insight |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1172/jci.insight.151039 |
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