Identification of sonic hedgehog-regulated genes and biological processes in the cranial neural crest mesenchyme by comparative transcriptomics

Abstract Background The evolutionarily conserved Sonic Hedgehog (Shh) signaling pathway is essential for embryogenesis and orofacial development. SHH ligand secreted from the surface ectoderm activates pathway activity in the underlying cranial neural crest cell (cNCC)-derived mesenchyme of the deve...

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Principais autores:	Joshua L. Everson, Dustin M. Fink, Hannah M. Chung, Miranda R. Sun, Robert J. Lipinski
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2018-06-01
Series:	BMC Genomics
Assuntos:	Sonic hedgehog Hedgehog target gene Cranial neural crest cell Frontonasal prominence Medial nasal process Orofacial development
Acceso en liña:	http://link.springer.com/article/10.1186/s12864-018-4885-5
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