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IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils

<p>Abstract</p> <p>Background</p> <p>The interplay between IFN-γ, IL-17 and neutrophils during CNS inflammatory disease is complex due to cross-regulatory factors affecting both positive and negative feedback loops. These interactions have hindered the ability to distinguish the relative contributio...

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Principais autores: Savarin Carine, Stohlman Stephen A, Hinton David R, Ransohoff Richard M, Cua Daniel J, Bergmann Cornelia C
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-05-01
coleção:Journal of Neuroinflammation
Assuntos:
Central nervous system
Encephalomyelitis
CD4<sup>+</sup> T cells
IFN-γ
IL-17
Neutrophils
Neurotropic coronavirus
Acesso em linha:http://www.jneuroinflammation.com/content/9/1/104
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