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Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ

Catabolism of the essential amino acid tryptophan is a key metabolic pathway contributing to the immunosuppressive tumor microenvironment and therefore a viable drug target for cancer immunotherapy. In addition to the rate-limiting enzyme indoleamine-2,3-dioxygenase-1 (IDO1), tryptophan catabolism v...

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Principais autores: Takumi Kudo, Mirja T. Prentzell, Soumya R. Mohapatra, Felix Sahm, Zhongliang Zhao, Ingrid Grummt, Wolfgang Wick, Christiane A. Opitz, Michael Platten, Edward W. Green
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2020-05-01
סדרה:Frontiers in Immunology
נושאים:
TDO2
glioblastoma
regulation
CEBPB
tryptophan
IL1B
גישה מקוונת:https://www.frontiersin.org/article/10.3389/fimmu.2020.00657/full
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