Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development

Dimethylarginine dimethylaminohydrolase (DDAH) is a highly conserved hydrolytic enzyme found in numerous species, including bacteria, rodents, and humans. In humans, the DDAH-1 isoform is known to metabolize endogenous asymmetric dimethylarginine (ADMA) and monomethyl arginine (l-NMMA), with ADMA pr...

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Principais autores:	Rhys B. Murphy, Sara Tommasi, Benjamin C. Lewis, Arduino A. Mangoni
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2016-05-01
coleção:	Molecules
Assuntos:	dimethylarginine dimethylaminohydrolase arginine nitric oxide asymmetric dimethylarginine monomethyl arginine enzyme inhibitors organic synthesis
Acesso em linha:	http://www.mdpi.com/1420-3049/21/5/615
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