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CD133-Dependent Activation of Phosphoinositide 3-Kinase /AKT/Mammalian Target of Rapamycin Signaling in Melanoma Progression and Drug Resistance

Melanoma frequently harbors genetic alterations in key molecules leading to the aberrant activation of PI3K and its downstream pathways. Although the role of PI3K/AKT/mTOR in melanoma progression and drug resistance is well documented, targeting the PI3K/AKT/mTOR pathway showed less efficiency in cl...

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Principais autores: Naji Kharouf, Thomas W. Flanagan, Abdulhadi A. Alamodi, Youssef Al Hmada, Sofie-Yasmin Hassan, Hosam Shalaby, Simeon Santourlidis, Sarah-Lilly Hassan, Youssef Haikel, Mossad Megahed, Robert T. Brodell, Mohamed Hassan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-01-01
Serier:Cells
Fag:
melanoma
CSCs
CD133
PI3K
AKT
mTOR
Online adgang:https://www.mdpi.com/2073-4409/13/3/240
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