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Effects of alpelisib treatment on murine Pten-deficient lipomas

Phosphatase and tensin homolog (PTEN) hamartoma tumour syndrome (PHTS) is a rare disorder caused by germline mutations in the tumour suppressor gene PTEN, a key negative regulator of phosphatidylinositol 3-kinase (PI3K)/AKT signalling. Children with PHTS often develop lipomas, for which only surgica...

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Principais autores: Lea M. Merz, Karsten Winter, Sandy Richter, Sonja Kallendrusch, Andreas Horn, Sonja Grunewald, Nora Klöting, Kerstin Krause, Wieland Kiess, Diana Le Duc, Antje Garten
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2025-12-01
coleção:Adipocyte
Assuntos:
Adipose tissue
phosphatidylinositol 3-kinase
phosphatase and tensin homolog
tissue slice culture
wortmannin
Acesso em linha:https://www.tandfonline.com/doi/10.1080/21623945.2025.2468275
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