Defined co-cultures of glutamatergic and GABAergic neurons with a mutation in DISC1 reveal aberrant phenotypes in GABAergic neurons

Abstract Background Mutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of mutated DISC1 represents a well-known and comprehensively characterized approach to understand neuropsychiatric disease mechanisms. However, previ...

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Egile Nagusiak:	Johanna Heider, Aaron Stahl, Denise Sperlich, Sophia-Marie Hartmann, Sabrina Vogel, Ricarda Breitmeyer, Markus Templin, Hansjürgen Volkmer
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2024-03-01
Saila:	BMC Neuroscience
Gaiak:	DISC1 E/I imbalance GABAergic neurons Glutamatergic neurons iPSC Co-culture
Sarrera elektronikoa:	https://doi.org/10.1186/s12868-024-00858-z
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