The function of PCSK9 in doxorubicin-induced cardiotoxicity and its underlying mechanism

Abstract Doxorubicin (DOX) is an anthracycline class of chemotherapy drug, the application of which is limited due to its cardiotoxic effects. Recombinant Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), is a serine protease pivotal in lipid metabolism and has a profound correlation with the o...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Shuai Shi, Zhihui Qin, Chang Liu, Yanru Zhao, Xiaopeng Bai, Chaoyu Sun, Xu Li, Wanting Cong, Xinyue Yuan, Lixiu Sun, Bingchen Liu, Xueqi Li
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Portfolio 2025-07-01
Σειρά:	Scientific Reports
Θέματα:	Doxorubicin PCSK9 KPNB1 Apoptosis Cardiotoxicity
Διαθέσιμο Online:	https://doi.org/10.1038/s41598-025-03419-4
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