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The modified mRNA vaccine protects immunocompromised AG129 mice from lethal challenge and multi-tissue infection by Zika virus

The multiple epidemics of Zika virus (ZIKV) posed a substantial threat to public health. Clinical evidence suggests that ZIKV could break through the blood–brain, blood-placenta, and blood-testis barriers, leading to severe outcomes such as congenital malformations in newborns and Guillain–Barré syn...

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Principais autores: Yuhuan Yan, Junbin Wang, Hao Yang, Yun Yang, Longhai Yuan, Cong Tang, Yanan Zhou, Qing Huang, Wenhai Yu, Xiaoming Liang, Dongdong Lin, Yanwen Li, Xuena Du, Yuxia Yuan, Rui Peng, Jiali Xu, Zhaolan Guo, Wenhao Xie, Wenqi Quan, Hongyu Chen, Jian Zhou, Shuaiyao Lu, Xiaozhong Peng
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2025-12-01
Serier:Emerging Microbes and Infections
Fag:
Zika virus
mRNA vaccine
lethal challenge
AG129 mice
antibody-dependent enhancement
Online adgang:https://www.tandfonline.com/doi/10.1080/22221751.2025.2556729
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