Gene-based Hardy–Weinberg equilibrium test using genotype count data: application to six types of cancers

Abstract Background An alternative approach to investigate associations between genetic variants and disease is to examine deviations from the Hardy–Weinberg equilibrium (HWE) in genotype frequencies within a case population, instead of case–control association analysis. The HWE analysis requires di...

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Autors principals:	Jo Nishino, Fuyuki Miya, Mamoru Kato
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-02-01
Col·lecció:	BMC Genomics
Matèries:	Hardy–Weinberg equilibrium test Gene-based analysis Cancer-related genes Allelic heterogeneity Recessive variants Genome-wide association study
Accés en línia:	https://doi.org/10.1186/s12864-025-11321-6
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