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The mannosyltransferase DPM1 regulates the activity of ER-stress sensor IRE1 in colorectal cancer

Abstract Most colorectal cancer (CRC) patients exhibit resistance to immune checkpoint blockade (ICB), limiting treatment efficacy. Activating the unfolded protein response sensor IRE1α in cancer cells can induce anticancer immune responses, yet its regulation remains unclear. Here we identify Dolic...

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Hoofdauteurs: Hussein Issaoui, Lina Zawil, Lola Bellone, Diogo Goncalves, Rachel Paul, Léa Di Mascio, Sonia Núñez-Vázquez, Sandrine Marchetti, Johanna Chiche, Nicolas Nottet, Simon Le Goupil, Hadrien Laprade, Lucile Bansard, Yourae Hong, Rebecca Wall, Sabine Tejpar, Caroline Truntzer, François Ghiringhelli, Suresh Poudel, Helen M. Beere, Douglas R. Green, Julie Pannequin, Eric Chevet, Jean-Ehrland Ricci
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2026-06-01
Reeks:Nature Communications
Online toegang:https://doi.org/10.1038/s41467-026-73942-z
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