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Communication Between Autophagy and Insulin Action: At the Crux of Insulin Action-Insulin Resistance?

Insulin is a paramount anabolic hormone that promotes energy-storage in adipose tissue, skeletal muscle and liver, and these responses are significantly attenuated in insulin resistance leading to type 2 diabetes. Contrasting with insulin’s function, macroautophagy/autophagy is a physiological mecha...

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Principais autores: Scott Frendo-Cumbo, Victoria L. Tokarz, Philip J. Bilan, John H. Brumell, Amira Klip
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-07-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
insulin resistance
autophagy
insulin action
obesity
type 2 diabetes
adipose tissue
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2021.708431/full
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