PARP inhibitors in the treatment of metastatic breast cancer patients with germline BRCA1/2 mutations. Experience of treatment with talazoparib in clinical practice

Germline BRCA1/2 mutations account for about 10% of all breast cancer. BRCA1/2 proteins are involved in homologous recombination - DNA double-strand break repair mechanism. Poly-(ADP ribose) polymerases (PARP) are required to repair DNA single-strand breaks through base excision repair. PARP inhibit...

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Autors principals:	M. A. Frolova, E. V. Glazkova, M. B. Stenina
Format:	Artigo
Idioma:	Russo
Publicat:	Remedium Group LLC 2020-07-01
Col·lecció:	Медицинский совет
Matèries:	brca-associated breast cancer parp inhibitors metastatic triple negative breast cancer olaparib talazoparib
Accés en línia:	https://www.med-sovet.pro/jour/article/view/5701
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