CAP-CD56+CD271+ BMSCs exos-loaded PVA/SA sustained-release hydrogel attenuates chondrocyte senescence and ameliorates lumbar facet joint osteoarthritis

Objective: This study aimed to develop a novel, targeted therapy for lumbar facet joint osteoarthritis (LFJ OA) by identifying a potent bone mesenchymal stem cell (BMSC) subpopulation for cartilage regeneration, engineering its exosomes (Exos) for specific delivery, and incorporating them into a sus...

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Detalhes bibliográficos

Principais autores:	Yong Xie, Quanbo Liu, Jinghua Tan, Yingjie Lu, Yunlong Li, Hongyi Ye, Zhun Xu, Ming Wang, Cheng Wang, Xuelin Li, Jingbo Xue, Yiguo Yan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	KeAi Communications Co., Ltd. 2026-03-01
coleção:	Bioactive Materials
Assuntos:	Lumbar facet joint osteoarthritis Bone marrow mesenchymal stem cell Engineered exosomes Senescence
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2452199X25004931
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