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Relevance of PSGL-1 Expression in B Cell Development and Activation

PSGL-1 is expressed in all plasma cells, but only in a small percentage of circulating B cells. Patients with systemic sclerosis (SSc) show reduced expression of PSGL-1 in B cells and increased prevalence of pulmonary arterial hypertension. PSGL-1 deficiency leads to a SSc-like syndrome and SSc-asso...

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Hlavní autoři: Rafael González-Tajuelo, Elena González-Sánchez, Javier Silván, Antonio Muñoz-Callejas, Esther Vicente-Rabaneda, Javier García-Pérez, Santos Castañeda, Ana Urzainqui
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020-11-01
Edice:Frontiers in Immunology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2020.588212/full
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