HSP90α induces immunosuppressive myeloid cells in melanoma via TLR4 signaling

Background Tumor cells modulate host immunity by secreting extracellular vesicles (EV) and soluble factors. Their interactions with myeloid cells lead to the generation of myeloid-derived suppressor cells (MDSC), which inhibit the antitumor function of T and NK cells. We demonstrated previously that...

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Autors principals:	Wei Li, Jochen Utikal, Xiaoying Hu, Viktor Umansky, Peter Altevogt, Rebekka Bitsch, Samantha Lasser, Alisa Lepper, Ihor Arkhypov, Feyza Gül Özbay Kurt, Daniel Novak, Vera Petrova, Thomas Hielscher, Christopher Groth
Format:	Artigo
Idioma:	Inglês
Publicat:	BMJ Publishing Group 2022-09-01
Col·lecció:	Journal for ImmunoTherapy of Cancer
Accés en línia:	https://jitc.bmj.com/content/10/9/e005551.full
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