CA72-4 derived from synovial cells inhibits monosodium urate-induced macrophage M1 polarization by activating the TIGIT/SHP-1 axis through binding to Siglec-15

Excessive M1 polarization of macrophages is a key driver of inflammatory processes in gout, while the regulatory mechanisms involved remain unclear. Herein, the role of carbohydrate antigen 72-4 (CA72-4), derived from human synovial cells (HFLS), in regulating macrophage M1 polarization during gout...

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Κύριοι συγγραφείς:	Honglei Hu, Xuefeng Bai, Lingyue Zhang, Hongmei Zhang, Qiang You, Shujuan Wang, Xueshan Bai
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Taylor & Francis Group 2026-12-01
Σειρά:	Autoimmunity
Θέματα:	Gout macrophage polarization CA72-4 Siglec-15 TIGIT/SHP-1 signaling
Διαθέσιμο Online:	https://www.tandfonline.com/doi/10.1080/08916934.2026.2649034
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