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Codon Optimization Leads to Functional Impairment of RD114-TR Envelope Glycoprotein

Lentiviral vectors (LVs) are a highly valuable tool for gene transfer currently exploited in basic, applied, and clinical studies. Their optimization is therefore very important for the field of vectorology and gene therapy. A key molecule for LV function is the envelope because it guides cell entry...

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Huvudupphov: Eleonora Zucchelli, Monika Pema, Anna Stornaiuolo, Claudia Piovan, Cinzia Scavullo, Erica Giuliani, Sergio Bossi, Stefano Corna, Claudia Asperti, Claudio Bordignon, Gian-Paolo Rizzardi, Chiara Bovolenta
Materialtyp: Artigo
Språk:Inglês
Utgiven: Elsevier 2017-03-01
Serie:Molecular Therapy: Methods & Clinical Development
Ämnen:
gene vector engineering
gene vector delivery
gene therapy
envelope glycoprotein
RD114-TR
codon optimization
lentiviral vector
RNA structure
packaging cell line
Länkar:http://www.sciencedirect.com/science/article/pii/S2329050117300062
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